Carbohydrate research

Synthesis of quinoline coupled [1, 2, 3]-triazoles as a promising class of anti-tuberculosis agents

KK Kumar, SP Seenivasan, V Kumar, TM Das

Index: Karthik Kumar; Prabu Seenivasan; Kumar, Vanaja; Mohan Das Carbohydrate Research, 2011 , vol. 346, # 14 p. 2084 - 2090

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Citation Number: 41

Abstract

A series of quinoline coupled 1, 2, 3-triazoles compounds have been synthesized by 'click chemistry'from azidomethyl quinoline with different alkynes. The efficiency and fidelity of the Cu (I)-catalyzed azide–alkyne reaction are substantiated by good yields and exclusive formation of the expected 1, 4-disubstituted triazole product. All the synthesized compounds were screened for anti-tubercular activity against Mycobacterium tuberculosis H37Rv by ...