New benzimidazoles as thrombopoietin receptor agonists

…, RM Keenan, AT Price, CL Erickson-Miller…

Index: Safonov, Igor G.; Heerding, Dirk A.; Keenan, Richard M.; Price, Alan T.; Erickson-Miller, Connie L.; Hopson, Christopher B.; Levin, Jenna L.; Lord, Kenneth A.; Tapley, Peter M. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 5 p. 1212 - 1216

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Citation Number: 40

Abstract

... C, 2 h, 95%; (c) 6-(3,4-dimethyl-phenyl)-pyridine-2-carbaldehyde, EtOH, H 2 O, NaHSO 3 , 60 °C, 64%; (d) LiAlH 4 , THF, −78 → 0 °C, 98%; (e) Dess–Martin periodinane, CH 2 Cl 2 , pyridine, 83%; (f) (carbethoxyethyl)triphenylphosphorane, CH 2 Cl 2 , rt, 95%; (g) MeOH, NaOH ... e) KJ Duffy, AT Price, E. Delorme, SB Dillon, C. Duquenne, C. Erickson-Miller, L. Giampa, Y. Huang, RM Keenan, P. Lamb, N ... f) H. Suzuki, T. Furukawa, C. Yamada, I. Shibuya, M. Kurumi, T ...