An efficient procedure for the synthesis of coumarin derivatives using TiCl 4 as catalyst under solvent-free conditions

H Valizadeh, A Shockravi

Index: Valizadeh, Hassan; Shockravi, Abbas Tetrahedron Letters, 2005 , vol. 46, # 20 p. 3501 - 3503

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Citation Number: 143

Abstract

The ability of titanium (IV) chloride as a catalyst to promote the Pechmann condensation reaction with a range of phenols and β-keto esters is described. The reaction was carried out by addition of TiCl4 to a mixture of the phenol and the β-keto ester with thorough stirring in the absence of a solvent and represents an improvement on the classical Pechmann conditions. The yields of coumarins obtained via this novel protocol were significantly ...