Synthesis, biological evaluation, and structure− activity relationships of dithiolethiones as inducers of cytoprotective phase 2 enzymes

…, CM Munday, AL Wilkins, J Babu

Index: Trebaul,C.; Teste,J. Bulletin de la Societe Chimique de France, 1969 , p. 2456 - 2462

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Citation Number: 19

Abstract

... J. Med ... We found that 3H-1,2-dithiole-3-thione itself (1, Table 1) and 5,6-dihydrocyclopenta[c]- 1,2-dithiole-3(4H)-thione (16, Table 1 ... Groups of female Sprague−Dawley rats were dosed with vehicle or the test compound by gavage at 7.5 (μmol/kg)/day for 10 days and sacrificed on ...