Synthesis and dopaminergic activity of 3??(3, 4??dihydroxyphenyl)??1??n??propylpyrrolidine hydrobromide

AM Crider, TF Hemdi, MN Hassan…

Index: Crider; Hemdi; Hassan; Fahn Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 11 p. 1585 - 1587

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Citation Number: 13

Abstract

Abstract 3-(3, 4-Dihydroxyphenyl)-1-n-propylpyrrolidine hydrobromide was synthesized by a six-step reaction sequence and was evaluated, and compared with apomorphine, for central dopaminergic agonist activity. The compound produced behavioral and biochemical changes characteristic of central dopaminergic stimulation. Administration of 3-(3, 4- dihydroxyphenyl)-1-n-propylpyrrolidine hydrobromide to rats resulted in the reversal of the ...