The Preparation of Partially Protected 3-Amino-1-methylpyrazole-5-carboxylic Acids to be Used as Intermediates in the Synthesis of Analogues of Distamycin A

L Ding, L Grehn, U Ragnarsson

Index: Ding, Lu; Grehn, Leif; Ragnarsson, Ulf Acta Chemica Scandinavica, 1990 , vol. 44, # 1 p. 75 - 81

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Citation Number: 4

Abstract

Partially protected 3-amino-1-methylpyrazole-5-carboxylic acid derivatives have been prepared by a convenient route from 3-amino-1-methylpyrazole. The structures of these compounds have been correlated with recent work in the field. Such derivatives, blocked on the amino function with tert—butyloxycarbonyl (6) or formyl (8) groups or on the carboxy function with benzyl (4a) or ethyl (4b) groups, should serve as suitable precursors for the ...