Studies on the Synthese of N-Heterocyclic Compounds. III. Hypocholesterolemic 1, 2, 4-Oxadiazole Derivatives (1)

S YURUGI, A MIYAKE, T FUSHIMI…

Index: Yurugi; Miyake; Fushimi; et al. Chemical and Pharmaceutical Bulletin, 1973 , vol. 21, # 8 p. 1641 - 1650

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Citation Number: 14

Abstract

3, 5-Disubstituted-1, 2, 4-oxadiazole derivatives containing aryl heteryl substituent at 3 position and amino, mercapto, aryl and heteryl substituent at 5 position have been synthesized. Among these compounds, 3-[4-(1-ethoxycarbonyl-1-methylethoxy) phenyl]-3-(3- pyridyl)-1, 2, 4-oxadiazole exhibited a considerable hypocholesterolemic activity.