Efficient preparation of 1, 4, 8-trimethylcyclam and its conversion into a thioalkyl-pendant pentadentate chelate
JA Halfen, VG Young Jr
Index: Halfen, Jason A.; Young Jr., Victor G. Chemical Communications, 2003 , # 23 p. 2894 - 2895
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Abstract
Tetraazamacrocycles such as 1,4,8,11-tetraazacyclotetradecane (cyclam) have a long history in synthetic inorganic chemistry and a burgeoning significance in medicinal chemistry. 1,2 Selective derivatization of the secondary amines in cyclam is a key step in the development of new ligands for transition metals and new bioactive agents alike. 3 Statistical methods using large excesses of cyclam in conjunction with yield-limiting quantities of electrophiles have been used to ...
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