Synthesis and tuberculostatic activity of novel N′??methyl??4??(pyrrolidin??1??yl) picolinohydrazide and N′??methylpyrimidine??2??carbohydrazide derivatives

…, H Foks, K Gobis, E Augustynowicz??Kopec

Index: Bogdanowicz, Agnieszka; Foks, Henryk; Gobis, Katarzyna; Augustynowicz-Kopec, Ewa Heteroatom Chemistry, 2012 , vol. 23, # 2 p. 223 - 230

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Abstract

Abstract The synthesis of N′-methyl-4-(pyrrolidin-1-yl) picolinohydrazide and N′-methyl- pyrimidine-2-carbohydrazide derivatives (5a and 5b) was carried out. These compounds were used as starting materials to obtain methyl N′-methylhydrazinecarbodithioates 6a and 6b, which, on reaction with either triethylamine or hydrazine, gave corresponding 1, 3, 4- oxadiazioles 7a and 7b or 1, 2, 4-triazoles 9a and 9b with the free NH 2 group at the N-4 ...