Synthesis and antineoplastic evaluations of 5, 8-bis [(aminoalkyl) amino]-1-azaanthracene-9, 10-diones

…, JJ Landi Jr, MP Hacker, JJ McCormack

Index: Krapcho; Landi Jr.; Hacker; McCormack Journal of Medicinal Chemistry, 1985 , vol. 28, # 8 p. 1124 - 1126

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Citation Number: 31

Abstract

Several 5, 8-bis [(aminoalkyl) amino]-l-azaanthracene-9, 10-diones have been synthesized and evaluated for antitumor activity against L1210 leukemia both in vitro and in vivo. Comparisons are made to the corresponding carbocyclic analogues. One of the aza analogues showed modest in vivo activity.