Ti-catalyzed regio-and enantioselective synthesis of unsaturated α-amino nitriles, amides, and acids. Catalyst identification through screening of parallel libraries

…, WG Wirschun, KW Kuntz, ML Snapper…

Index: Porter; Wirschun; Kuntz; Snapper; Hoveyda Journal of the American Chemical Society, 2000 , vol. 122, # 11 p. 2657 - 2658

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Citation Number: 106

Abstract

Due to the significance of R-amino acids in chemistry and biology, the search for efficient methods that lead to the formation of these important compounds in the optically pure form continues. 1 Several procedures have been devised that afford R-amino acids in high selectivity, but many of these protocols rely on the use of chiral auxiliaries. 2 Other approaches depend on catalytic enantioselective reduction of dehydroamino acids, and ...