Olefin Cyclopropanation by a Sequential Atom??Transfer Radical Addition and Dechlorination in the Presence of a Ruthenium Catalyst

K Thommes, G Kiefer, R Scopelliti…

Index: Thommes, Katrin; Kiefer, Gregor; Scopelliti, Rosario; Severin, Kay Angewandte Chemie - International Edition, 2009 , vol. 48, # 43 p. 8115 - 8119

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Citation Number: 37

Abstract

Cyclopropanes can be found in a number of biologically active compounds, and methods for the synthesis of this smallest carbocycle have been investigated extensively.[1] Most often, cyclopropanations are performed with Simmons–Smith-type reagents or by transition metal catalyzed reactions of olefins with diazo compounds.[1] Cyclopropanes can also be synthesized by reductive coupling of 1, 3-dihalogen derivatives. Reagents, which can ...