Synthesis of lecithin analogs by means of cyclic enediol phosphates. Derivatives of 1-octadecanol and of cholesterol

F Ramirez, H Okazaki, JF Marecek

Index: Ramirez,F. et al. Journal of Organic Chemistry, 1978 , vol. 43, p. 2331 - 2334

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Citation Number: 4

Abstract

Results Lipophilic Alcohols (RIOH) as" First Alcohol"(R'OH) in the Phosphorylation Sequence. Procedure 1. Three alcohols of increasing lipophilicity, 2-methyl-1-propanol (3a), 1-octadecanol (3b), and cholesterol (3c), are converted into the corresponding alkyl phosphorylcholine zwitterions, la-c, following the sequence of reactions shown in Scheme 111. The first step is the phosphorylation of the alcohol by the cyclic enediol phosphor~ ...