Aza-analogs of dibenzo [c, h] cinnoline

SK Singh, AL Ruchelman, N Zhou…

Index: Singh, Sudhir K.; Ruchelman, Alexander L.; Zhou, Nai; Li, Tsai-Kun; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J. Medicinal Chemistry Research, 2003 , vol. 12, # 1 p. 1 - 12

Full Text: HTML

Citation Number: 6

Abstract

摘要2, 3-Dimethoxy-8, 9-methylenedioxydibenzo [c, h] cinnoline 1 exhibits greater topoisomerase I (TOP1)-targeting activity and cytotoxicity than its benzo [i] phenanthridine analog. 1, 5, 6-, 5, 6, 11-, and 5, 6, 12-Triazachrysene analogs were prepared to determine the influence of further aza-substitution on TOP1-targeting activity and cytotoxicity. The data reinforce the structure-activity relationships previously observed and indicate that a ...