Potential antipsychotic agents. 6. Synthesis and antidopaminergic properties of substituted N-(1-benzyl-4-piperidinyl) salicylamides and related compounds. QSAR …

…, Y Kumar, S Rämsby, SO Ögren, T Högberg

Index: De Paulis; Hall; Kumar; Ramsby; Ogren; Hogberg European Journal of Medicinal Chemistry, 1990 , vol. 25, # 6 p. 507 - 517

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Citation Number: 11

Abstract

Abstract A number of substituted 2-methoxybenzamides, with and without 6-hydroxy groups, with 4-piperidinyl side-chains have been synthesized and evaluated for their antidopaminergic properties. The salicylamides were found to require a lipophilic N- substituent, like a benzyl group, for high affinity for the dopamine D-2 binding site in contrast to salicylamides with 2-pyrrolidinylmethyl side-chains. Furthermore, the influence of the ...