Novel synthesis of indolizidines and quinolizidines
KA Tehrani, M D'hooghe, N De Kimpe
Index: Tehrani, Kourosch Abbaspour; D'hooghe, Matthias; De Kimpe, Norbert Tetrahedron, 2003 , vol. 59, # 17 p. 3099 - 3108
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Citation Number: 32
Abstract
A very short synthesis of indolizidines, quinolizidines and some higher homologues was developed by alkylation of 2-methyl-1-pyrroline or 6-methyl-2, 3, 4, 5-tetrahydropyridine with 1, 3-or 1, 4-dihaloalkanes, followed by reduction of the intermediate iminium salts, resulting in the desired 1-azabicyclo [mn 0] alkanes in good yields.
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