1, 5-Diarylsubstituted 1, 2, 3-triazoles as potassium channel activators. VI
…, V Calderone, I Giorgi, O Livi, E Martinotti, A Martelli…
Index: Biagi, Giuliana; Calderone, Vincenzo; Giorgi, Irene; Livi, Oreste; Martinotti, Enrica; Martelli, Alma; Nardi, Antonio Farmaco, 2004 , vol. 59, # 5 p. 397 - 404
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Citation Number: 55
Abstract
As part of our program toward designing potassium channel openers, synthesis of a novel series of 1, 5-diphenylsubstituted 1, 2, 3-triazoles, as potential activators of the large- conductance calcium-activated potassium channels (BK), as well as their vasorelaxant activity are presented. The functional effect of these potential structurally novel BK-openers on vascular contractile function were studied in vitro, using isolated rat aortic rings pre- ...
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