Journal of medicinal chemistry

β-Hydroxyphenethylamino Derivatives of Various Nitrogen Heterocycles

DE Heitmeier, AP Gray

Index: Heitmeier,D.E.; Gray,A.P. Journal of Medicinal Chemistry, 1964 , vol. 7, p. 288 - 293

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Citation Number: 5

Abstract

The S-substituted mandelamides (Table 11) were obtained in 36 (V, T'I) to 717,(IT') yield by acylation of an aminoheterocycle with (+)-mandelic acid in refluxing xylene with azeotropic removal of water, or under milder conditions and in better yield (83-92%; I, 11, 111, and VII) by reaction with (+)-0-acetylmandelyl chloride in ether (or tetrahydrofuran)-triethylamine, or in cold pyridine. 4-Mandelamido-1, 2, 4-triazole (V) and 4-mandelamido-3, 5-dimethyl-1, 2 ...