Deproto-metallation and computed CH acidity of 2-aryl-1, 2, 3-triazoles

F Chevallier, T Blin, E Nagaradja, F Lassagne…

Index: Chevallier, Floris; Blin, Thomas; Nagaradja, Elisabeth; Lassagne, Frederic; Roisnel, Thierry; Halauko, Yury S.; Matulis, Vadim E.; Ivashkevich, Oleg A.; Mongin, Florence Organic and Biomolecular Chemistry, 2012 , vol. 10, # 25 p. 4878 - 4885

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Citation Number: 28

Abstract

2-Aryl-1, 2, 3-triazoles were synthesized by cyclization of the corresponding glyoxal arylosazones, generated from commercial arylhydrazines. The deproto-metallation of 2- phenyl-1, 2, 3-triazole was attempted using different 2, 2, 6, 6-tetramethylpiperidino-based mixed lithium–metal (Zn, Cd, Cu, Co, Fe) combinations, giving results in the case of Zn, Cd, and Cu. The lithium–zinc combination was next selected to apply the deprotonation– ...