Tetrahedron

N-arylation of 3-alkoxypyrazoles, the case of the pyridines

S Guillou, FJ Bonhomme, DB Chahine, O Nesme…

Index: Guillou, Sandrine; Bonhomme, Frederic J.; Chahine, Di Betina; Nesme, Olivier; Janin, Yves L. Tetrahedron, 2010 , vol. 66, # 14 p. 2654 - 2663

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Citation Number: 20

Abstract

Abstract In the course of a research program focused on the preparation of libraries of new chemical entities derived from 3-alkoxypyrazoles, we studied their N-pyridylation using 2, 3 or 4-bromopyridines. This was achieved using Cristau and Taillefer copper-catalyzed arylation method and mostly led to the 3-alkoxy-1H-pyrazol-1-yl pyridine isomer along with lesser amount of the alternative 5-alkoxy-1H-pyrazol-1-yl pyridine. The structures of these ...