Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARδ-selective agonists

…, T Suzuki, H Nakagawa, M Ogura, M Makishima…

Index: Fujieda, Hiroki; Usui, Shinya; Suzuki, Takayoshi; Nakagawa, Hidehiko; Ogura, Michitaka; Makishima, Makoto; Miyata, Naoki Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 15 p. 4351 - 4357

Full Text: HTML

Citation Number: 15

Abstract

To find novel PPARδ-selective agonists, we designed and synthesized phenylpropanoic acid derivatives bearing 6-substituted benzothiazoles. Optimization of this series led to the identification of a potent and selective PPARδ agonist 17. Molecular modeling suggested that compound 17 occupies the Y-shaped pocket of PPARδ appropriately.