A convenient asymmetric synthesis of thalidomide
S Robin, J Zhu, H Galons, PH Chuong, JR Claude…
Index: Robin, Sylvie; Zhu, Jiarong; Galons, Herve; Pham-Huy, Chuong; Claude, Jean Roger; et al. Tetrahedron: Asymmetry, 1995 , vol. 6, # 6 p. 1249 - 1252
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Citation Number: 32
Abstract
Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Benzyloxyamine reacted with BOC-glutamic-α-phenyl ester in the presence of carbodiimide to give BOC-amino-N-benzyloxypiperidinedione. Deprotection of the amino group followed by phthaloylation led to N-benzyloxythalidomide which was then converted into thalidomide.
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