Synthesis of 3-hydroxypyrimidine-2, 4-diones. Addition of anilines to benzyloxy isocyanate synthons to give N-hydroxyureas
JL Romine, SW Martin, NA Meanwell, JR Epperson
Index: Romine; Martin; Meanwell; Epperson Synthesis, 1994 , # 8 p. 846 - 850
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Citation Number: 9
Abstract
A review of the literature yielded few reports that dealt with the utility of alkoxy isocyanates. 5 This is because most attempts to generate them have been unsuccessful due to their tendency to trimerize. 6 In 1960, McKay iso-lated the 1, 3, 5-tribenzyloxyisocyanuric acid 2 when tri-ethylamine was added to a solution of benzyloxyarnine hydrochloride and phosgene which had been heated at reflux in chlorobenzene7 (Scheme 2). In the ...
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