Journal of medicinal chemistry

Inhibition of human leukocyte elastase, porcine pancreatic elastase, and chymotrypsin by elasnin and other 4-hydroxy-2-pyrones

RW Spencer, LJ Copp, JR Pfister

Index: Spencer, Robin W.; Copp, Leslie J.; Pfister, Juerg R. Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1828 - 1832

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Citation Number: 28

Abstract

Elasnin and 15 related 4-hydroxy-2-pyrones have been assayed for in vitro inhibition of human leukocyte elastase, porcine pancreatic elastase, and bovine chymotrypsin. Inhibition constants for HL elastase range from 0.1 to 10 mM. The principal determinant of potency against the elastases is probably the substituent at position 3, which may account for the observed strong homology between the elastases in their inhibition by these compounds. ...