Synthesis and biological evaluation of hydroxylated 3-phenylcoumarins as antioxidants and antiproliferative agents
J Yang, GY Liu, F Dai, XY Cao, Y Kang, LM Hu…
Index: Yang, Jie; Liu, Guo-Yun; Dai, Fang; Cao, Xiao-Yan; Kang, Yan-Fei; Hu, Li-Mei; Tang, Jiang-Jiang; Li, Xiu-Zhuang; Li, Yan; Jin, Xiao-Ling; Zhou, Bo Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6420 - 6425
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Citation Number: 39
Abstract
Based on the observed biological activities of coumarins and resveratrol, we synthesized fourteen hydroxylated 3-phenylcoumarins (stilbene-coumarin hybrids) including six novel ortho-hydroxy-methoxy substituted derivatives, 1–14, by Perkin reaction. We characterized these compounds concerning their antioxidant activity against 2, 2′-azobis (2- amidinopropane hydrochloride)(AAPH)-induced pBR322 DNA strand breakage, and their ...
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