The design, synthesis and activity of non-ATP competitive inhibitors of pp60 c-Src tyrosine kinase. Part 2: hydroxyindole derivatives

KL Milkiewicz, TH Marsilje, RP Woodworth…

Index: Milkiewicz, Karen L.; Marsilje, Thomas H.; Woodworth Jr., Richard P.; Bifulco Jr., Neil; Hangauer, Matthew J.; Hangauer, David G. Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 5 p. 483 - 486

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Citation Number: 20

Abstract

Protein tyrosine kinases (PTKs) are enzymes that catalyze the transfer of the γ-phosphate of ATP to the hydroxyl group of tyrosine in proteins. pp60 c-src is the parent of the 'src' sub-class of PTKs known as the non-receptor PTKs. pp60 c-src binds to various growth factor receptor PTKs, as well as the focal adhesion associated PTK. Formation of these signaling complexes results in synergistic activation of the associated PTKs, triggering enhanced cell growth ...

Arylacetamide κ opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity

[Le Bourdonnec, Bertrand; Ajello, Christopher W.; Seida, Pamela R.; Susnow, Roberta G.; Cassel, Joel A.; Belanger, Serge; Stabley, Gabriel J.; DeHaven, Robert N.; DeHaven-Hudkins, Diane L.; Dolle, Roland E. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2647 - 2652]

Arylacetamide κ opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity

The design, synthesis and activity of non-ATP competitive inhibitors of pp60 c-Src tyrosine kinase. Part 2: hydroxyindole derivatives

Abstract

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