Novel synthetic 9-benzyloxyacridine analogue as both tyrosine kinase and topoisomerase I inhibitor

XL Lang, QS Sun, YZ Chen, LL Li, CY Tan…

Index: Lang, Xu-Liang; Sun, Qin-Sheng; Chen, Yu-Zong; Li, Lu-Lu; Tan, Chun-Yan; Liu, Hong-Xia; Gao, Chun-Mei; Jiang, Yu-Yang Chinese Chemical Letters, 2013 , vol. 24, # 8 p. 677 - 680

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Citation Number: 3

Abstract

Multi-target agents against tyrosine kinases and topoisomerases are potentially useful for the effective treatment of cancers. Discovery of new multi-target scaffolds are important for developing such agents. A series of five novel acridine analogues, LXL 1–5, were synthesized and their antiproliferative activity against HepG-2 cell lines were evaluated, among which the 9-benzyloxyacridine analogue, LXL-5, showed inhibitory activity against ...