Diazen-1-ium-1, 2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its …

…, MA Chowdhury, Y Dong, C Velázquez, D Das…

Index: Abdellatif, Khaled R.A.; Chowdhury, Morshed Alam; Dong, Ying; Velazquez, Carlos; Das, Dipankar; Suresh, Mavanur R.; Knaus, Edward E. Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 22 p. 9694 - 9698

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Citation Number: 23

Abstract

A new class of hybrid nitric oxide-releasing anti-inflammatory (AI) ester prodrugs (NONO- coxibs 12a–b) wherein an O2-acetoxymethyl 1-(2-carboxypyrrolidin-1-yl) diazen-1-ium-1, 2- diolate (11, O2-acetoxymethyl PROLI/NO) NO-donor moiety was covalently coupled to the bromomethyl group of 5-(4-bromomethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl- 1H-pyrazole (9a), and its methanesulfonyl analog (9b), were synthesized. The diazen-1- ...