Tetrahedron

Synthetic studies toward (+)-cortistatin A

Z Wang, M Dai, PK Park, SJ Danishefsky

Index: Wang, Zhang; Dai, Mingji; Park, Peter K.; Danishefsky, Samuel J. Tetrahedron, 2011 , vol. 67, # 52 p. 10249 - 10260

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Citation Number: 11

Abstract

We describe herein the synthesis of a late-stage intermediate en route to cortistatin A. Key transformations included a Snieckus-like cascade sequence culminating in a 6π- electrocyclization, an alkylative dearomatization, and the stereoselective functionalization of the cortistatin A-ring. While the total synthesis we sought was not accomplished, the work sets the stage for several approaches to the preparation of novel analogs via diverted total ...