Process Development of a Novel Azetidinyl Ketolide Antibiotic

B Li, TV Magee, RA Buzon, DW Widlicka…

Index: Organic Process Research and Development, , vol. 16, # 5 p. 788 - 797

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Abstract

... bacterial pneumonia (CABP) and biodefense pathogens.(5) Efforts in our antibacterial research program led to ... The process efficiency could be greatly improved by telescoping the steps. ... an aqueous workup for the acetylation step was still needed, the organic phase could be ...

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Process Development of a Novel Azetidinyl Ketolide Antibiotic

[Li, Bryan; Magee, Thomas V.; Buzon, Richard A.; Widlicka, Daniel W.; Bill, Dave R.; Brandt, Thomas; Cao, Xiaoping; Coutant, Michael; Dou, Haijian; Granskog, Karl; Flanagan, Mark E.; Hayward, Cheryl M.; Li, Bin; Liu, Fengwei; Liu, Wei; Nguyen, Thuy-Trinh; Raggon, Jeffrey W.; Rose, Peter; Rainville, Joseph; Reilly, Usa Datta; Shen, Yue; Sun, Jianmin; Wilcox, Glenn E. Organic Process Research and Development, 2012 , vol. 16, # 5 p. 788 - 797]

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