2′??O??aminoethyl oligoribonucleotides containing novel base analogues: Synthesis and triple??helix formation at pyrimidine/purine inversion sites

S Buchini, CJ Leumann

Index: Buchini, Sabrina; Leumann, Christian J. European Journal of Organic Chemistry, 2006 , # 14 p. 3152 - 3168

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Citation Number: 16

Abstract

Abstract The synthesis of a common sugar intermediate for the 2′-aminoethyl- ribonucleoside synthesis in 9 steps and an overall yield of 33% starting from D-ribose is described. This intermediate was successfully used for the synthesis of the 2′-aminoethyl- ribonucleosides containing the bases thymine (t), 5-methylcytosine (c), 5-methyl-2- pyrimidinone (x), 2-aminopurine (ap) and guanine (g). These were subsequently ...