Rational design of potent GSK3β inhibitors with selectivity for Cdk1 and Cdk2

D Lesuisse, G Dutruc-Rosset, G Tiraboschi…

Index: Lesuisse, Dominique; Dutruc-Rosset, Gilles; Tiraboschi, Gilles; Dreyer, Matthias K.; Maignan, Sebastien; Chevalier, Alain; Halley, Frank; Bertrand, Philippe; Burgevin, Marie-Claude; Quarteronet, Dominique; Rooney, Thomas Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 6 p. 1985 - 1989

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Citation Number: 17

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... From an HTS hit, a series of potent and selective inhibitors of GSK3β have been designed based on a Cdk2-homology model and with the help of several crystal structures of the compounds within Cdk2. ... From an HTS hit, a series of potent and selective inhibitors of GSK3β have been ...