A facile total synthesis for large-scale production of imatinib base

A Kompella, BRK Adibhatla…

Index: Organic Process Research and Development, , vol. 16, # 11 p. 1794 - 1804

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Citation Number: 10

Abstract

... C–N coupling reaction with the use of an organic phosphorous reagent ... figure Scheme 6. Schematic synthetic procedure for 4-(4-methylpiperazinomethyl)benzoic acid ... a basis and thoroughly studying and optimizing parameters, thereby making the process commercially viable ...