Potent and selective mitogen-activated protein kinase kinase (MEK) 1, 2 inhibitors. 1. 4-(4-Bromo-2-fluorophenylamino)-1-methylpyridin-2 (1 H)-ones

EM Wallace, J Lyssikatos, JF Blake, J Seo…

Index: Journal of Medicinal Chemistry, , vol. 49, # 2 p. 441 - 444

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Citation Number: 38

Abstract

... Journal of Medicinal Chemistry. ... 9 Both ARRY-142886 and 2 are superior to 1 in both pharmaceutical properties and preclinical efficacy. 6,7 Reports from the clinic on these promising inhibitors are just starting to emerge. ...