Palladium-Catalyzed Intramolecular Hydroarylation of 4-Benzofuranyl Alkynoates. Approach to Angelicin Derivatives
T Kitamura, K Otsubo
Index: Kitamura, Tsugio; Otsubo, Kensuke Journal of Organic Chemistry, 2012 , vol. 77, # 6 p. 2978 - 2982
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Citation Number: 25
Abstract
Intramolecular hydroarylation of 4-benzofuranyl alkynoates using Pd (OAc) 2 as catalyst took place selectively and efficiently, giving angular furocoumarin derivatives in high yields. The parent angelicin was obtained in 80% yield by this method. The starting 4-benzofuranyl alkynoates were easily accessible from readily available 4-hydroxybenzofurans and alkynoic acids.
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