Synthesis

Synthesis of N6-[endo-2′-(endo-5′-Hydroxy) norbornyl]-8-(N-methylisopropylamino)-9-methyladenine (WRC-0571): A Potent and Selective Adenosine A1 Receptor …

C Jin, JP Burgess, KS Rehder, GA Brine

Index: Jin, Chunyang; Burgess, Jason P.; Rehder, Kenneth S.; Brine, George A. Synthesis, 2007 , # 2 p. 219 - 224

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Citation Number: 8

Abstract

Abstract A new versatile synthesis of N 6-[endo-2′-(endo-5′-hydroxy) norbornyl]-8-(N- methylisopropylamino)-9-methyladenine (WRC-0571), a highly potent and selective antagonist for adenosine A 1 receptor, is presented. The overall yield is 14%. The key step involved the stereoselective reduction of endo-2-(diphenylmethylamino) norbornan-5-one to generate the endo-5-hydroxy substituent using the Luche reagent (NaBH 4-CeCl 3) at-40 ...