Tricyclic Quinoxalinediones: 5, 6-Dihydro-1H-pyrrolo [1, 2, 3-de] quinoxaline-2, 3-diones and 6, 7-Dihydro-1H, 5H-pyrido [1, 2, 3-de] quinoxaline-2, 3-diones as Potent …

…, N Tanno, T Kodo, N Ae, H Yamaguchi…

Index: Nagata, Ryu; Tanno, Norihiko; Kodo, Toru; Ae, Nobuyuki; Yamaguchi, Hiroshi; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 23 p. 3956 - 3968

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Citation Number: 77

Abstract

A series of tricyclic quinoxalinediones, 5, 6-dihydro-W-pyrrolo [l, 2, 3-delquinoxaline-2, 3- diones and 6, 7-dihydro-lH, 5H-pyrido [1, 2, 3-de] quinoxaline-2, 3-diones, were synthesized and was evaluated for their affinity for the glycine binding site of the NMDA receptor using a [3H]-5, 7-dichlorokynurenic acid binding assay. The six-membered ring-fused tricyclic quinoxalinedione 18g (Ki= 9.9 nM) displayed high affinity for the glycine site. The anilide ...