Model compounds for the active site selenocysteine of glutathione peroxidase: A 77Se NMR study

D Dowd, P Gettins

Index: Dowd, Diane; Gettins, Peter Magnetic Resonance in Chemistry, 1988 , vol. 26, p. 1 - 3

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Citation Number: 22

Abstract

Abstract To test the feasibility of using 77 Se NMR to distinguish between different proposed mechanisms of action of the selenoenzyme glutathione peroxidase, model compounds containing the proposed selenium moieties have been synthesized and their 77 Se NMR spectra recorded. It was found that the difference in chemical shift between the two proposed resting states, selenol or selenenic acid, is approximately 1300 ppm. For the next step, ...