Tetrahedron letters

Synthesis of nucleobase-functionalized β-peptoids and β-peptoid hybrids

X Mejías, L Feliu, M Planas, E Bardají

Index: Mejias, Xavier; Feliu, Lidia; Planas, Marta; Bardaji, Eduard Tetrahedron Letters, 2006 , vol. 47, # 46 p. 8069 - 8071

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Citation Number: 10

Abstract

Over the past 25 years, the highly specific recognition through the natural pairing of nucleobases has prompted the design of nucleic acid mimetics as promising drug candidates in molecular biology and diagnostics. 1 Of the many structural motifs examined, peptide nucleic acids (PNAs) have emerged as the most successful oligonucleotide surrogates. 2 PNAs stand out in terms of their structural simplicity and ability to bind sequences specifically to ssRNA and ...