Highly selective inhibitors of thromboxane synthetase. 1. Imidazole derivatives

…, M Nakazawa, T Tanouchi, M Kawamura…

Index: Iizuka; Akahane; Momose; Nakazawa; Tanouchi; Kawamura; Ohyama; Kajiwara; Iguchi; Okada; Taniguchi; Miyamoto; Hayashi Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1139 - 1148

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Citation Number: 205

Abstract

The structure-activity relationships of imidazole derivatives as inhibitors of thromboxane (TX) synthetase were investigated. Introduction of various Substituents (eg, one or two methyl groups, a halogen atom, a methylidene group, unsaturated bonds, or a phenylene group) into the a position or other positions in the carboxy-bearing side chain of 1-(7-carboxyheptyl) imidazole (15) was found to increase the inhibitory potency. The length of the side chains ...