Cleavage of 2??(Arylamino)??4, 6??dimethoxypyrimidines To Yield Arylguanidines

JW Shaw, DH Grayson, I Rozas

Index: Shaw, Julian W.; Grayson, David H.; Rozas, Isabel European Journal of Organic Chemistry, 2014 , vol. 2014, # 17 p. 3565 - 3569

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Abstract

Abstract A novel method for the synthesis of aryl-substituted guanidines in good overall yields is presented; it consists of the acidic cleavage of 2-(arylamino)-4, 6- dimethoxypyrimidines, which were prepared by coupling aryl bromides with 2-amino-4, 6- dimethoxypyrimidine. This methodology introduces a new means of protection for the guanidine functionality.