An efficient one-pot synthesis, structure, antimicrobial and antioxidant investigations of some novel quinolyldibenzo [b, e][1, 4] diazepinones

NJ Parmar, HA Barad, BR Pansuriya, SB Teraiya…

Index: Parmar, Narsidas J.; Barad, Hitesh A.; Pansuriya, Bhavesh R.; Teraiya, Shashikant B.; Gupta, Vivek K.; Kant, Rajni Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 11 p. 3816 - 3821

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Citation Number: 21

Abstract

A highly improved one-pot procedure for the synthesis of diazepinones, which incorporate a bioactive quinoline nucleus, under catalyst-, and solvent-free environment has been developed. The method allowed us to achieve the products in high yields without requiring a chromatographic separation. All new quinolyldibenzo [b, e][1, 4] diazepinones 6a–h thus obtained were further treated to achieve N10–allylated products 7a–h by a simple ...