Journal of fluorine chemistry

Enhanced nucleophilic fluorination and radiofluorination of organosilanes appended with potassium-chelating leaving groups

MH Al-huniti, S Lu, VW Pike, SD Lepore

Index: Al-Huniti, Mohammed H.; Lu, Shuiyu; Pike, Victor W.; Lepore, Salvatore D. Journal of Fluorine Chemistry, 2014 , vol. 158, p. 48 - 52

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Citation Number: 7

Abstract

Abstract Here we aimed to explore the feasibility of enhancing the fluorination of organosilanes by appending potassium-chelating groups to the substrates. For this purpose, eight organosilanes were prepared in which a linear or cyclic leaving group, with putative potassium-chelating ability, was attached covalently to a congested silicon atom via an ether linkage to serve as a potential nucleophilic assisting leaving group (NALG). Organosilicon ...

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