Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter: Part 3. A potential 5-HT transporter imaging agent, 3-(3-[18 F] fluoropropyl)-6- …

…, BS Lee, DY Chi, YS Choe, SE Kim, YS Song…

Index: Lee, Byoung Se; Chu, Soyoung; Lee, Kyo Chul; Lee, Bon-Su; Chi, Dae Yoon; Choe, Yearn Seong; Kim, Sang Eun; Song, Yun Seon; Jin, Changbae Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 4949 - 4958

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Citation Number: 16

Abstract

3-(3-[18F] Fluoropropyl)-6-nitroquipazine ([18F] FPNQ) as a 5-HT transporter imaging agents was designed, synthesized, and evaluated. FPNQ was selected due to its potent in vitro biological activity (Ki= 0.32 nM) in rat brain cortical membranes. The 18F-labeled FPNQ was prepared by reaction of the propyl mesylate as a precursor with tetra-n-butylammonium [18F] fluoride generated under NCA conditions. The precursor mesylate was synthesized ...