Asymmetric aldol reaction catalyzed by a heterogenized proline on a mesoporous support. The role of the nature of solvents

…, F Sanchez, A Fernandez-Mayoralas

Index: Doyagueez, Elisa G.; Calderon, Felix; Sanchez, Felix; Fernandez-Mayoralas, Alfonso Journal of Organic Chemistry, 2007 , vol. 72, # 24 p. 9353 - 9356

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Citation Number: 92

Abstract

A heterogenized (S)-proline on mesoporous support MCM-41 catalyzes the asymmetric aldol reaction in a wide range of solvents. The progress of the reaction is dependent on the nature of the solvent. Reactions proceed more efficiently in hydrophilic polar solvents; however, the addition of a small amount of water has a positive effect on the rate and the stereoselectivity of the reaction performed in hydrophobic toluene. The reaction under ...