Nucleotides. Part LIII. 6??Aminohexanoyl??linked conjugates of monomeric and trimeric cordycepin

M Wasner, W Pfleiderer, RJ Suhadolnik…

Index: Wasner, Marita; Suhadolnik, Robert J.; Horvath, Susan E.; Adelson, Martin E.; Kon, Ning; Guan, Ming-Xu; Henderson, Earl E.; Pfleiderer, Wolfgang Helvetica Chimica Acta, 1997 , vol. 80, # 4 p. 1061 - 1072

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Citation Number: 8

Abstract

Abstract To improve cell permeability, monomeric 3′-deoxyadenosine (cordycepin) and antivirally active trimeric 3′-deoxyadenylyl-(2′–5′)-3′-deoxyadenylyl-(2′–5′)-3′- deoxyadenosine (2′–5′) d 3 (AAA);(cordycepin-trimer core) were modified at the 2′-O-or 5′-O-position by myristic, cholic, and folic acid= tetradecanoic, 3α, 7α, 12α-trihy-droxy-5β- cholan-24-oic, and N-{4-{[(2-amino-3, 4-dihydro-4-oxopteridin-6-yl) methyl] amino} ...