Efficient Solution??Phase Parallel Synthesis of 4??Substituted N??Protected Piperidines

…, AM Kauppi, R Olsson, F Almqvist

Index: Wang, Xiaoyang; Kauppi, Anna M.; Olsson, Roger; Almqvist, Fredrik European Journal of Organic Chemistry, 2003 , # 23 p. 4586 - 4592

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Abstract

Abstract Practical conditions for the synthesis of 4-substituted N-protected piperidines through CuCN· 2LiBr-catalyzed organozinc additions to 1-acylpyridinium salts and subsequent hydrogen-transfer hydrogenation have been established. The reaction sequence is performed at room temperature and provides 4-substituted N-protected piperidines in excellent overall yields without the isolation of intermediate ...