A novel class of AMPA receptor allosteric modulators. Part 1: design, synthesis, and SAR of 3-aryl-4-cyano-5-substituted-heteroaryl-2-carboxylic acid derivatives

MC Fernandez, A Castaño, E Dominguez…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 19 p. 5057 - 5061

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Citation Number: 23

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... Intermediate 13a was further elaborated to give a wide range of derivatives summarized in Scheme 2. Thiophenes 6c–f were obtained by coupling of primary thiols with 13a in toluene, using palladium chemistry. ...