Tetrahedron letters

Use of 2-oxazolidinones as latent aziridine equivalents. III. Preparation of N-substituted piperazines

GS Poindexter, MA Bruce, KL LeBoulluec, I Monkovic

Index: Poindexter, Graham S.; Bruce, Marc A.; LeBoulluec, Karen L.; Monkovic, Ivo Tetrahedron Letters, 1994 , vol. 35, # 40 p. 7331 - 7334

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Citation Number: 17

Abstract

Abstract A number of N-aryl and N-alkyl substituted piperazines 1 were prepared from variously substituted 2-oxazolidinone derivatives 3. The method involved treatment of 3 with HBr in glacial acetic acid followed by heating the resulting ring-opened salts 5 in alcoholic solvent. The piperazines 1a–1q were isolated by crystallization in yields ranging from 23– 91%.