The discovery of new spirocyclic muscarinic M 3 antagonists

…, N Kindon, G Pairaudeau, J Theaker, DJ Warner

Index: Stocks, Michael J.; Alcaraz, Lilian; Bailey, Andrew; Bowers, Keith; Donald, David; Edwards, Helen; Hunt, Fraser; Kindon, Nicholas; Pairaudeau, Garry; Theaker, Jill; Warner, Daniel J. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 24 p. 7458 - 7461

Full Text: HTML

Citation Number: 11

Abstract

... free, Log D 2.2, MWt 405) and work is continuing in our laboratories to further optimize the chemical series. Acknowledgements. The authors thank Dr. Simon Teague and Dr. Tim Luker for helpful discussions. References and notes. 1; RM Eglen; Prog. Med. Chem., 43 (2005), p. 105. ... 2; I. Peretto, P. Petrillo, BP Imbimbo; Med. Res. Rev., 29 (2009), p. 867. ... Dramane I. Laine; Expert Rev. Clin. Pharmacol., 3 (2010), p. 43. ... M. Cazzola, MG Matera; Br. J. Pharmacol., 155 ...